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折扣/货期| 货号：38448 | 规格：2.7 mg | 目录价：￥3556 |
产品详情
产品名称:
8-Chloroadenosine-5'-triphosphate (sodium salt)
别名:
8-chloro ATP
产品描述:
8-Chloroadenosine-5’-triphosphate (8-chloro ATP) is an active metabolite of the anticancer agent 8-chloro cAMP and a derivative of the nucleotide adenosine 5’-triphosphate (ATP; Item No. 14498).{69006} It is formed from 8-chloro cAMP via 8-chloroadenosine (Item No. 35766) and mono- and diphosphate intermediates. 8-chloro ATP accumulates for up to 12 hours following application of 8-chloro cAMP or 8-chloroadenosine and is associated with inhibition of cell growth, decreases in endogenous ATP levels, and a reduction in RNA, but not DNA, synthesis in patient-derived multiple myeloma cells. It inhibits topoisomerase II-α-dependent relaxation of supercoiled pUC19 DNA when used at concentrations of 1.5 to 8 mM, as well as reduces topoisomerase II-α-catalyzed ATP hydrolysis by 50% at 1 mM, in K562 human myelocytic leukemia cells.{68366}
保存温度:
-80
运输温度:
-80
预期分子量:
629.6
产品形式:
A solution in water
有效期:
730
纯度:
≥95%
CAS号:
793671-47-3
分子式:
C10H11ClN5O13P3 • 4Na
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下一个:2'(3')-O-(5-Chloroanthraniloyl)adenosine-5'-O-triphosphate (sodium salt)
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