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折扣/货期| 货号：SPR-488B | 规格：100 µg | 目录价：￥7774.2 |
产品详情
产品名称:
Amyloid Beta 1-42 Oligomers
别名:
Abeta Oligomers, Abeta peptide, Amyloid beta peptide oligomers, Beta amyloid peptide oligomers, amyloid beta precursor protein peptide oligomers, APP
产品描述:
Human Synthetic Amyloid Beta 1-42 Oligomers
反应种属:
Human
实验应用:
WB | In vivo Assay | In vitro Assay
纯化方式:
N/A
偶联:
No Tag
产品浓度:
1 mg/ml
表达系统:
N/A
保存温度:
-80ºC
运输温度:
Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
预期分子量:
4.5 kDa
存储溶液:
Phosphate buffer (PB) pH 7.4 and 10 mM NaCl
产地:
加拿大
功能与背景:
Our Amyloid Beta 1-42 (Aβ42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (1,2). Our Aβ42 oligomers present as globular oligomers when observed under TEM and AFM, and have a unique dimer/trimer and oligomer signal on a Western Blot with an anti-amyloid beta antibody. Our Aβ42 oligomers were also demonstrated to be toxic to primary rat cortical neurons in a dose-dependent manner.
In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Soluble Aβ oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function (4). Aβ oligomers generated in vitro were toxic to PC12 cells (5) and SH-SY5Y cells (6). Aβ was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients (7) and accumulations of Aβ were shown to be associated with lower survival rates in Parkinson’s disease patients with dementia (8).
纯度:
>95%
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