Amyloid-β Monoclonal Antibody (Clone 6C3, MOAB-2)-单抗-ELISA_抗体_蛋白_核苷酸

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Amyloid-β Monoclonal Antibody (Clone 6C3, MOAB-2)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：11610

规格：200 µg

目录价：￥4760

产品详情

产品名称:

Amyloid-β Monoclonal Antibody (Clone 6C3, MOAB-2)

别名:

Aβ

产品描述:

Amyloid plaques composed primarily of the 42 amino acid form of amyloid-β peptide (Aβ42) are a hallmark of Alzheimer’s disease (AD). However, the roles of the various amyloid β peptide(s), especially Aβ42, related to the neurotoxicity characteristic of AD remains unclear. A major hindrance to evaluating the role of Aβ in AD pathology has been the availability of anti-Aβ antibodies to selectively detect Aβ versus amyloid precursor protein (APP), Aβ40 versus Aβ42, and specific conformations of the peptide, particularly oligomeric forms. MOAB-2 (mouse IgG2b) is a pan-specific antibody specific to Aβ (residues 1-4) that differentiates intracellular Aβ from APP. MOAB-2 does not detect APP in cell culture media/lysates or in brain homogenates from transgenic mice expressing 5 familial AD mutation (5xFAD mice). Intraneuronal Aβ was confirmed by co-localization of MOAB-2 immunoreactivity with C-terminal antibodies specific for Aβ40 and Aβ42, and with cathepsin-D, a lysosomal marker. Additionally, MOAB-2 demonstrates strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues.{20683}

宿主来源:

Mouse

实验应用:

ELISA, WB

同种型:

IgG2b

免疫原:

Oligomeric form of amyloid-β peptide (Aβ42)

克隆号:

6C3

保存温度:

-20