货号:11610 | 规格:200 µg | 目录价:¥4760 |
产品详情
产品名称:
Amyloid-β Monoclonal Antibody (Clone 6C3, MOAB-2)
别名:
Aβ
产品描述:
Amyloid plaques composed primarily of the 42 amino acid form of amyloid-β peptide (Aβ42) are a hallmark of Alzheimer’s disease (AD). However, the roles of the various amyloid β peptide(s), especially Aβ42, related to the neurotoxicity characteristic of AD remains unclear. A major hindrance to evaluating the role of Aβ in AD pathology has been the availability of anti-Aβ antibodies to selectively detect Aβ versus amyloid precursor protein (APP), Aβ40 versus Aβ42, and specific conformations of the peptide, particularly oligomeric forms. MOAB-2 (mouse IgG2b) is a pan-specific antibody specific to Aβ (residues 1-4) that differentiates intracellular Aβ from APP. MOAB-2 does not detect APP in cell culture media/lysates or in brain homogenates from transgenic mice expressing 5 familial AD mutation (5xFAD mice). Intraneuronal Aβ was confirmed by co-localization of MOAB-2 immunoreactivity with C-terminal antibodies specific for Aβ40 and Aβ42, and with cathepsin-D, a lysosomal marker. Additionally, MOAB-2 demonstrates strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues.{20683}
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG2b
免疫原:
Oligomeric form of amyloid-β peptide (Aβ42)
克隆号:
6C3
保存温度:
-20
运输温度:
-20
产品形式:
200 µg of protein G-purified antibody
有效期:
1095
上一个:Thioredoxin 1 Truncated (human) Monoclonal Antibody (Clone 7D11)
下一个:Prion Protein Monoclonal Antibody (Clone SHA31)
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