Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2)
货号:13492 | 规格:1 ea | 目录价:¥6462 |
产品详情
产品名称:
Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2)
别名:
AR|NR3C4|Nuclear Receptor Subfamily 3 Group C Member 4
产品描述:
The androgen receptor (AR) is an ~100 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy’s disease, and male infertility. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. IGF-1 activates the PI3K/AKT pathway in LNCap at high passage number and increases phosphorylation of the AR at Ser213/210 and Ser791/790.{17381} The western blot results also show that inhibition of the PI3K/Akt pathway by LY294002 prior to incubation with IGF-1 suppressed AR phosphorylation at Ser213/210. Activation of the PI3K/Akt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.
宿主来源:
Mouse
实验应用:
IHC (paraffin-embedded), WB
同种型:
IgG1κ
免疫原:
Synthetic peptide from human androgen receptor amino acids 207-221
克隆号:
156C135.2
保存温度:
-20
运输温度:
-20
产品形式:
100 µl of protein G-affinity purified monoclonal antibody
有效期:
365
来源:
Animal/Mouse
上一个:DNA Methyltransferase 3a Monoclonal Antibody (Clone 64B1446)
下一个:Histone H3 (Phospho-Ser28) Monoclonal Antibody (Clone 117C826)
您可能感兴趣的产品
IL18 antibody [HL2938]
货号:GTX640322-S
Human Parechovirus 1+3 VP3 antibody [HL2443]
货号:GTX640154-S
C3a Receptor antibody [HL2855]
货号:GTX640126-S
CCR2 antibody [HL2838]
货号:GTX640109-S
TIGIT antibody [HMV322] HistoMAX™
货号:GTX639946-S
PD-L1 antibody [H302] HistoMAX™
货号:GTX639925-S
FSH Receptor antibody [HL2784]
货号:GTX639652-S
P2X5 antibody [HL2773]
货号:GTX639638-S
促销活动
相关产品推荐
5-methyl-2'-deoxy Cytidine ELISA Monoclonal Antibody
货号:489332
Prostaglandin E2 ELISA Monoclonal Antibody
货号:414013
11-dehydro Thromboxane B2 Monoclonal Antibody
货号:419512
Prostaglandin D2 ELISA Monoclonal Antibody
货号:412032
Prostaglandin D2 Express ELISA Monoclonal Antibody
货号:412042
Vitamin D ELISA Monoclonal Antibody
货号:401052