Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2)-单抗-ELISA_抗体_蛋白_核苷酸

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Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：13492

规格：1 ea

目录价：￥6462

产品详情

产品名称:

Androgen Receptor (Phospho-Ser210,213) Monoclonal Antibody (Clone 156C135.2)

别名:

AR|NR3C4|Nuclear Receptor Subfamily 3 Group C Member 4

产品描述:

The androgen receptor (AR) is an ~100 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy’s disease, and male infertility. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. IGF-1 activates the PI3K/AKT pathway in LNCap at high passage number and increases phosphorylation of the AR at Ser213/210 and Ser791/790.{17381} The western blot results also show that inhibition of the PI3K/Akt pathway by LY294002 prior to incubation with IGF-1 suppressed AR phosphorylation at Ser213/210. Activation of the PI3K/Akt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.

宿主来源:

Mouse

实验应用:

IHC (paraffin-embedded), WB

同种型:

IgG1κ

免疫原:

Synthetic peptide from human androgen receptor amino acids 207-221

克隆号:

156C135.2

保存温度:

-20