Anti-5-hydroxy Methylcytosine Rabbit Monoclonal Antibody (Clone RM236)-单抗-ELISA_抗体_蛋白_核苷酸

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Anti-5-hydroxy Methylcytosine Rabbit Monoclonal Antibody (Clone RM236)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：20723

规格：50 µg

目录价：￥7952

产品详情

产品名称:

Anti-5-hydroxy Methylcytosine Rabbit Monoclonal Antibody (Clone RM236)

别名:

5-hmC

产品描述:

5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification formed from the oxidation of 5-methylcytosine by Tet dioxygenases.{17171} 5-hmC is primarily a stable DNA modification, but it can be oxidized by Tet enzymes and its products further modified to generate nonmethylated cytosine, indicating a role as an intermediate in DNA demethylation as well.{49667,29364,49668} It is associated with actively transcribed genes and recognized by a variety of proteins, including proteins involved in DNA repair and DNA metabolic processes.{49667,49668} 5-hmC has been found in all mammalian tissues but levels are higher in the brain relative to other tissues.{49669} The percentage of genomic 5-hmC in mouse cerebellum increases during postnatal development until adulthood, and genes acquiring intragenic 5-hmC are enriched in pathways associated with age-related neurodegenerative disease pathways in adult mice.{20327} In contrast, 5-hmC levels are reduced by up to 8-fold in cancer tissues.{49667,49670} Cayman’s 5-Hydroxymethylcytosine Polyclonal Antibody can be used for dot blot, ELISA, hydroxymethylated DNA immunoprecipitation (hMeDIP), immunocytochemistry (ICC), and immunohistochemistry (IHC) applications.

宿主来源:

Rabbit

实验应用:

Dot blot, ELISA, hMeDIP, ICC, and IHC

同种型:

IgG

免疫原:

BSA-conjugated 5-hydroxy methylcytosine

克隆号:

RM236

保存温度:

-20