货号:AG-20A-0042-C050 | 规格:50 ug | 目录价:¥1200 |
货号:AG-20A-0042-C100 | 规格:100 ug | 目录价:¥1920 |
产品详情
产品名称:
anti-IL-33, mAb (IL33068A)
别名:
Interleukin-33; IL-1F11; NF-HEV
产品描述:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
实验应用:
ELISA, WB
靶标/特异性:
Recognizes human IL-33. Weakly cross-reacts with mouse IL-33.
同种型:
Mouse IgG2bkappa
免疫原:
Recombinant human IL-33.
克隆号:
IL33068A
产品浓度:
1mg/ml
保存温度:
-20°C
运输温度:
BLUE ICE
产品形式:
liquid
存储溶液:
Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
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