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折扣/货期| 货号：AG-20B-0026-C100 | 规格：100 ug | 目录价：￥3840 |
产品详情
产品名称:
anti-TRAIL (human), mAb (HS501)
别名:
Apo-2L; TNFSF10; CD253
产品描述:
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC). .
宿主来源:
Purified from concentrated hybridoma tissue culture supernatant.
实验应用:
WB
靶标/特异性:
Recognizes human TRAIL.
同种型:
Mouse IgG1
免疫原:
Recombinant human TRAIL.
克隆号:
HS501
产品浓度:
1 mg/ml
保存温度:
-20°C
运输温度:
BLUE ICE
产品形式:
liquid
存储溶液:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
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