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折扣/货期| 货号：10946 | 规格：50 µg | 目录价：￥5110 |
产品详情
产品名称:
ASH2L (human recombinant)
别名:
Absent, small, or homeotic discs 2-like|Set1/Ash2 Histone Methyltransferase Complex Subunit Ash2 Isoform A
产品描述:
ASH2L is the human homolog of the Drosophila absent, small or homeotic discs 2 (ash2) gene product, a member of the trithorax group (TrxG) of proteins.{19552} The TrxG gene products in Drosophila and their mammalian homologs are responsible for controlling gene transcription. The ASH2L protein is a component of various multisubunit protein complexes, including the large complex of proteins associated with the SET1 (MLL) family of lysine methyltransferases.{19554} ASH2L, along with WDR5 and RbBP5, form the human MLL1 core protein complex.{19551} MLL1-5 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation.{19556} Post-translational modifications of ASH2L have also been described showing methylation of Arg-296 by protein-arginine methyltransferease 1 (PRMT1) in vitro and in cells and by PRMT5 in vitro.{19555} Further experimental evidence in rats suggests that ASH2L cooperates with Ha-RAS to transform rat embryonic fibroblasts, implicating ASH2L as a novel oncoprotein.{19553}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol
有效期:
180
纯度:
≥90%
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