货号:13913 | 规格:1 ea | 目录价:¥6318 |
产品详情
产品名称:
Caspase-8 Monoclonal Antibody (Clone 90A992)
产品描述:
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.{18384} The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation, and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into an a2b2 tetramer to form the active enzyme. Caspase-8 (FLICE) forms a direct link between the activation of CD95 and the caspase pathway. Overexpression of caspase-8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family.
宿主来源:
Mouse
实验应用:
FC, IHC (paraffin-embedded tissue), and WB
同种型:
IgG1
免疫原:
human caspase-8 amino acids PVETDSEEQP
克隆号:
90A992
保存温度:
-20
运输温度:
-20
产品形式:
100 µg Protein G purified IgG1 in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide
有效期:
180
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