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折扣/货期| 货号：22809 | 规格：100 µg | 目录价：￥5544 |
产品详情
产品名称:
CdnP (Mycobacterium tuberculosis strain ATCC 25618/H37Rv recombinant)
别名:
3'(2'),5'-Bisphosphate Nucleotidase|3'-Phosphoadenosine 5'-phosphate Phosphatase|Bifunctional Oligoribonuclease and PAP Phosphatase NrnA|CnpB|Cyclic di-NMP Phosphodiesterase|PAP Phosphatase|Rv2837c
产品描述:
Cyclic dinucleotide phosphodiesterase (CdnP) is a soluble phosphodiesterase involved in regulating cyclic dinucleotide signaling during intracellular infections of M. tuberculosis.{36095} It is composed of an N-terminal Asp-His-His (DHH) domain and a C-terminal DHH-associated (DHHA1) domain that catalyze the hydrolysis of cyclic dinucleotides. CdnP hydrolyzes a variety of cyclic dinucleotides, including cyclic di-AMP (Item No. 17753), cyclic di-GMP (Item No. 17144), and 2′3′-cGAMP (Item No. 19887), which decreases their recognition by the stimulator of interferon genes (STING), a key mediator in the host innate immune response.{36905,33472,36906} Knockout of the gene encoding CdnP, CnpB, increases the production of IFN-β in isolated mouse bone marrow-derived macrophages (BMDMs) infected with CnpB-/- M. tuberculosis, as well as decreases pulmonary and splenic bacterial burden and increases survival in CnpB-/- M. tuberculosis-infected mice.{36097} Cayman’s CdnP (Mycobacterium tuberculosis strain ATCC 25618H37Rv recombinant) protein contains N-terminal Trx- and His-tags followed by a thrombin cleavage site and an S-tag followed by an enterokinase cleavage site.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride
有效期:
365
纯度:
≥70% estimated by SDS-PAGE
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