DNA Methyltransferase 1 Monoclonal Antibody (Clone 60B1220.1)-单抗-ELISA_抗体_蛋白_核苷酸

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DNA Methyltransferase 1 Monoclonal Antibody (Clone 60B1220.1)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：13479

规格：1 ea

目录价：￥6660

产品详情

产品名称:

DNA Methyltransferase 1 Monoclonal Antibody (Clone 60B1220.1)

别名:

DNMT1

产品描述:

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The DNMT3 family members, DNMT3a and DNMT3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. DNMT1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. DNMT1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase, and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.

宿主来源:

Mouse

实验应用:

WB, IHC (paraffin-embedded sections), ChIP, and IP

同种型:

IgG1κ

免疫原:

synthetic peptide corresponding to amino acids 637-650 (EKDDREDKENAFKR) of human DNMT1

克隆号:

60B1220.1

保存温度:

-20