DNA Methyltransferase 3a Monoclonal Antibody - Biotinylated (Clone 64B814.1)-单抗-ELISA_抗体_蛋白_核苷酸

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DNA Methyltransferase 3a Monoclonal Antibody - Biotinylated (Clone 64B814.1)

品牌：Cayman

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说明书

折扣/货期

货号：13483

规格：1 ea

目录价：￥6786

产品详情

产品名称:

DNA Methyltransferase 3a Monoclonal Antibody - Biotinylated (Clone 64B814.1)

别名:

DNMT3a

产品描述:

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The DNMT3 family members, DNMT3a, and DNMT3b are strongly expressed in embryonic stem (ES) cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of DNMT3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.

宿主来源:

Mouse

实验应用:

ELISA

同种型:

IgG1

免疫原:

recombinant mouse DNMT3a expressed in bacteria

克隆号:

64B814.1

保存温度:

运输温度: