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折扣/货期| 货号：10755 | 规格：50 µg | 目录价：￥5544 |
产品详情
产品名称:
G9a-like protein (human recombinant)
别名:
EHMT1|Eu HMTase 1|Euchromatic Histone-Lysine N-Methyltransferase 1|GLP|KMT1D
产品描述:
Post-translational modification of histones by methylation of lysine residues can promote transcriptional activation or repression. G9a-like protein (GLP) and G9a are SET domain-containing methyltransferases that specifically mono- and di-methylate histone H3 at lysine 9 (H3K9).{19158,19156} Methylation of H3K9 by a GLP/G9a heteromeric complex regulates gene expression by silencing euchromatin.{19160} GLP and G9a share 80% sequence identity in their SET domains. Structure-activity relationship (SAR) studies have been employed to design potent and selective inhibitors of these proteins, including BIX-01294 and UNC0638, with IC50 values in the nanomolar range.{18376}
保存温度:
-80
运输温度:
-80
有效期:
545
纯度:
≥95% estimated by SDS-PAGE
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