Gasdermin D (mouse) ELISA Kit-小鼠ELISA试剂盒-ELISA_抗体_蛋白_核苷酸

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Gasdermin D (mouse) ELISA Kit

品牌：Adipogen

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说明书

折扣/货期

货号：AG-45B-0011-KI01

规格：96 wells

目录价：￥7080

产品详情

产品名称:

Gasdermin D (mouse) ELISA Kit

别名:

Gasdermin Domain-containing Protein 1; Gasdermin-D (C-terminal); GSDMD-CT; Gsdmd

产品描述:

Inflammasomes are multimeric protein complexes that comprise a sensor (e.g. NLRP3), an adaptor (ASC/Pycard) and the procaspase-1. An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1, which further induces maturation of interleukin-1beta and -18 (IL-1beta and IL-18) through proteolytic cleavage of pro-IL-1beta and pro-IL-18. Activated caspase-1, and also the recently characterized caspase-11 non-canonical inflammasome pathway, also cleave the intracellular gasdermin D, which leads to a particular form of inflammatory cell death called pyroptosis. The gasdermin family members contain N-terminal domains that are capable of forming membrane pores to induce cytolysis, whereas the C-terminal domains of gasdermins function as inhibitors of such cytolysis through intramolecular domain association. Caspase-1 or -11 cleavage of gasdermin D is required for regulation of pyroptosis: upon protease cleavage of the gasdermin N- and C-domain linker, the disruption of the intramolecular domain interaction in the presence of lipids releases the N-domain to assemble oligomeric membrane pores that trigger cell death. Gasdermin D seems to be a key effector in the LPS-induced lethal sepsis.

靶标/特异性:

Detects full-length and cleaved mouse Gasdermin D (C-terminus) in cell culture supernatants and cell extracts. Does not cross-react with human or rat gasdermin D.

保存温度:

+4°C

运输温度:

BLUE ICE

有效期:

12 months after the day of manufacturing. See expiry date on ELISA Kit box.

产地:

瑞士

灵敏度:

14pg/ml

检测范围:

15.6 to 1000pg/ml