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折扣/货期| 货号：33738 | 规格：10 µg | 目录价：￥7236 |
产品详情
产品名称:
GSK3β (human, recombinant)
别名:
Glycogen Synthase Kinase 3β|GSK3B|Serine/threonine-protein Kinase GSK3B
产品描述:
Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity.{60859,60860} It is composed of an N-terminal β-strand domain, a kinase domain, and a C-terminal α-helical domain.{60861} GSK3β is constitutively active, ubiquitously expressed, and localizes predominantly to the cytosol but is also found in the nucleus and mitochondria.{60860,60862} It is inhibited by phosphorylation at serine 9 (Ser9), which is mediated by a variety of kinases, including PKA, PKB, and Akt, and has roles in insulin, growth factor, and Wnt signaling pathways.{60860} GSK3β is involved in several pathophysiological conditions, such as diabetes, cancer, inflammation, and neurological or psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and bipolar disorder.{60862,60859} Cayman's GSK3β (human, recombinant) protein can be used for enzymatic activity assays.
宿主来源:
Insect cells
保存温度:
-80
运输温度:
-80
产品形式:
Active recombinant human GST-tagged, His-tagged GSK3β expressed in insect cells
有效期:
180
纯度:
≥90% estimated by SDS-PAGE
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