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折扣/货期| 货号：19380 | 规格：50 µg | 目录价：￥5964 |
产品详情
产品名称:
HDAC8 (human, recombinant)
别名:
Histone Deacetylase 8
产品描述:
Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the zinc-dependent deacetylation of core histones.{14467,14468} It is composed of a single α/β domain with an N-terminal deacetylase active site, which can be disrupted by phosphorylation of a proximal serine.{66421} HDAC8 is ubiquitously expressed in human tissues and, unlike most other HDACs, is localized to both the cytosol and nucleus.{66422} It associates with other proteins and transcription factors to regulate gene expression. HDAC8 has a flexible active site that can deacetylate lysines from both histone tails and cytosolic proteins.{66421} It deacetylates pyruvate kinase M2 (PKM2), inducing its relocalization to the nucleus where it binds β-catenin and promotes cyclin D1 expression and cell cycle progression in HepG2 hepatocellular carcinoma (HCC) cells.{66423} HDAC8 associates with RUNX family transcription factor 1 (RUNX1) and suppresses the expression of RUNX1-regulated genes, which code for proteins involved in cytokine expression, cell differentiation, cell cycle progression, and tumor suppression, in COS-7 cells.{66424} Inhibition of HDAC8 decreases tumor volume and increases intratumoral apoptosis without reducing body weight in a neuroblastoma mouse xenograft model.{66426} Cayman’s HDAC8 (human, recombinant) protein can be used for enzyme activity assay and Western blot applications.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 7.5, with 200 mM NaCl, 2.5 mM potassium chloride, 1 mM TCEP, and 25% glycerol
有效期:
180
纯度:
≥80% estimated by SDS-PAGE
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