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折扣/货期| 货号：10009466 | 规格：10 µg | 目录价：￥9108 |
产品详情
产品名称:
HDAC9 (human, recombinant)
别名:
Histone Deacetylase 9
产品描述:
HDAC9 is a Class IIa HDAC which is homologous to the yeast HDAC1 and is larger in size than the other classes of HDACs.{14467,14468} Class IIa HDACs contain a highly conserved C-terminal deacetylase catalytic domain (~420 amino acids) and N-terminal domain with no similarity to HDACs in other classes. Class II HDACs can shuttle between the nucleus and cytoplasm, suggesting possible extranuclear functions including regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play an important role in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.{14467,14468} Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.{14468}
保存温度:
-80
运输温度:
-80
产品形式:
40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 20% glycerol, and 200 mM imidazole
有效期:
180
纯度:
≥75% estimated by SDS-PAGE
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