Histone H3K27Me3 Monoclonal Antibody (Clone RM175)-单抗-ELISA_抗体_蛋白_核苷酸

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Histone H3K27Me3 Monoclonal Antibody (Clone RM175)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：20719

规格：100 µg

目录价：￥7408

产品详情

产品名称:

Histone H3K27Me3 Monoclonal Antibody (Clone RM175)

别名:

Trimethylated Histone H3 Lysine 27

产品描述:

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Trimethylation of histone H3 at lysine 27 (H3K27Me3) is associated with gene silencing.{42743} It is involved in tumor progression through its regulation by enhancer of zeste homolog 2 (EZH2) and transcriptional repression of tumor suppressor genes.{49135,49132} Levels of H3K27Me3 are reduced in 293 T-REx cells containing EEDR236T and SUZ12G610V mutations and in lymphoblastoid cells isolated from patients with Weaver syndrome, a rare overgrowth disorder characterized by EZH2, EED, or SUZ12 mutations, cancer susceptibility, and various distinctive physical features.{49133} Cayman’s Histone H3K27Me3 Monoclonal Antibody can be used for chromatin immunoprecipitation (ChIP), ELISA, immunohistochemistry (IHC), multiplex-based assay, and Western blot (WB) applications.

宿主来源:

Rabbit

实验应用:

ChIP, ELISA, IHC, multiplex-based assays, WB

同种型:

IgG

免疫原:

Peptide corresponding to H3K27Me3

克隆号:

RM175

保存温度:

-20