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折扣/货期| 货号：22738 | 规格：50 µg | 目录价：￥3388 |
产品详情
产品名称:
Hsp60 (human, recombinant)
别名:
Chaperonin 60|Cpn60|Heat Shock Protein 60|HSPD1|Mitochondrial Matrix Protein P1
产品描述:
Heat shock protein 60 (Hsp60), also known as heat shock protein family D member 1 (HspD1), is an approximately 60 kDa protein that functions as a molecular chaperone.{35046} It belongs to the type I subclass of chaperonins and is found in eubacteria, mitochondria, and chloroplasts where its expression is induced by stress. Hsp60 primarily exists as a heptameric ring that it is converted to a tetradecameric double-ring structure in the presence of ATP.{36472} Within mitochondria, it associates with its co-chaperone, Hsp10, to form a barrel-like structure and refold proteins that have been shuttled to the mitochondria in an ATP-dependent manner.{36472,35047} Hsp60 also has extramitochondrial functions such as the production of proinflammatory cytokines in human leukocytes and activation of innate immune receptors.{35048,36473} Hsp60 expression is increased in the serum and saliva of patients with type 2 diabetes mellitus and mutations in HSPD1 lead to neurodegenerative diseases.{36473,35049}
保存温度:
-80
运输温度:
-80
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
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