货号:13923 | 规格:1 ea | 目录价:¥6462 |
产品详情
产品名称:
IκBα (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413)
产品描述:
NF-κB is silenced in the cytoplasm by an inhibitory protein IκB.{18565} Synthesis of IκBα is autoregulated.{18566} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18543,18544,18545,18540} External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to activation of the IκB-kinase complex that specifically phosphorylates IκBa on serine32 and serine36. Phosphorylation of these sites leads to ubiquitination of IκBα and subsequent degradation by the 26S proteasome. Degradation of IκBα results in unmasking of the nuclear localization signal of NF-κB dimers, which subsequently translocate to the nucleus and activate target genes.{18541,18542} Six members of the IκB family members have been identified.{18565} one of the first genes induced following NF-κB activation is IκBα.
宿主来源:
Mouse
实验应用:
WB and IP
同种型:
IgG1κ
免疫原:
synthetic peptide containing phosphorylated serine residues corresponding to human IκBα amino acids 32 and 36
克隆号:
39A1413
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% gelatin and 0.05% sodium azide
有效期:
180
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