IκBα (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413)-单抗-ELISA_抗体_蛋白_核苷酸

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IκBα (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：13923

规格：1 ea

目录价：￥6462

产品详情

产品名称:

IκBα (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413)

产品描述:

NF-κB is silenced in the cytoplasm by an inhibitory protein IκB.{18565} Synthesis of IκBα is autoregulated.{18566} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18543,18544,18545,18540} External stimuli such as tumor necrosis factor or other cytokines initiates a signal transduction cascade that leads to activation of the IκB-kinase complex that specifically phosphorylates IκBa on serine32 and serine36. Phosphorylation of these sites leads to ubiquitination of IκBα and subsequent degradation by the 26S proteasome. Degradation of IκBα results in unmasking of the nuclear localization signal of NF-κB dimers, which subsequently translocate to the nucleus and activate target genes.{18541,18542} Six members of the IκB family members have been identified.{18565} one of the first genes induced following NF-κB activation is IκBα.

宿主来源:

Mouse

实验应用:

WB and IP

同种型:

IgG1κ

免疫原:

synthetic peptide containing phosphorylated serine residues corresponding to human IκBα amino acids 32 and 36

克隆号:

39A1413

保存温度:

-20