官网链接
折扣/货期| 货号：22811 | 规格：100 µg | 目录价：￥6790 |
产品详情
产品名称:
IRF3 (human, recombinant)
别名:
Interferon Regulatory Factor 3
产品描述:
Interferon regulatory factor 3 (IRF3) is a member of the IRF family. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity.{39335,39336,39338,39337,39339} Double-stranded RNA generated during a viral infection leads to IRF3 activation by serine/threonine phosphorylation by TBK1 or IKBKE kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREBBP.{39335,39336,39338,39334} The complex, known as DRAF1, activates transcription interferons alpha and beta, as well as other interferon-induced genes.{39335,39334} These genes play a critical role in type 1 interferon (IFN)-dependent immune response.{39339} A recent study shows phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF recruits and specifies IRF3 phosphorylation and activation by the serine/threonine-protein kinase TBK1, thereby inducing the production of type-1 interferons.{39336,39337,39340}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥85% as estimated by SDS-PAGE
您可能感兴趣的产品
Human Aldolase C protein
货号：GTX67212-pro
Human Sorbitol Dehydrogenase protein (active)
货号：GTX67160-pro
Human Fumarate hydratase protein (active)
货号：GTX66998-pro
beta Galactosidase protein
货号：GTX04676-pro
Human Lysozyme protein (active)
货号：GTX03701-pro
Human Flavin reductase protein
货号：GTX67254-pro
Human Aspartoacylase protein
货号：GTX67242-pro
Human Aldolase C protein (active)
货号：GTX66923-pro
促销活动
