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折扣/货期| 货号：11299 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
JMJD2A (human, recombinant; Strep-tagged)
别名:
JHDM3A|Jumonji Domain Containing 2A|KDM4A|Lysine (K)-specific Demethylase 4A
产品描述:
Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression.{18003} Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase.{17969} It catalyzes the demethylation of trimethylated forms of histone at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an α-ketoglutarate-dependent Fe (II) oxygenase.{17970} Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin.{20824} JMJD2A’s transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes.{17969} Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.{18003}
保存温度:
-80
运输温度:
-80
产品形式:
20 mM HEPES, pH 7.4, and 150 mM NaCl
有效期:
180
纯度:
≥95% estimated by SDS-PAGE
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