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折扣/货期| 货号：38166-1 mg | 规格：1 mg | 目录价：￥1232 |
| 货号：38166-10 mg | 规格：10 mg | 目录价：￥6426 |
| 货号：38166-5 mg | 规格：5 mg | 目录价：￥3864 |
| 货号：38166 | 规格：500 µg | 目录价：￥644 |
产品详情
产品名称:
Klotho-derived Peptide 1 (56-87) (human) (trifluoroacetate salt)
别名:
KP1 (56-87)
产品描述:
Klotho-derived peptide 1 (KP1) (56-87) is a peptide derived from human Klotho protein, which has roles in disrupting TGF-β signaling.{65760} It binds to TGF-β receptor type 1 (TGFBR2), and TGF-β receptor type 2 (TGFBR2; Kds = 1.41 and 14.6 µM, respectively). Preincubation with KP1 (10 µg/ml) inhibits TGF-β-induced increases in fibronectin and α-smooth muscle actin (α-SMA) levels in NRK-49F rat fibroblasts. In vivo, KP1 (1 mg/kg per day) selectively localizes to damaged kidneys and reduces serum creatine and blood urea nitrogen levels, markers of kidney function, as well as reduces kidney fibrosis, in mouse models of unilateral ureteral obstruction (UUO) and unilateral ischemia-reperfusion injury-induced renal fibrosis.
保存温度:
-20
运输温度:
-20
预期分子量:
3228.4
产品形式:
A solid
有效期:
1460
纯度:
≥95%
分子式:
C149H203N39O43 • XCF3COOH
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