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折扣/货期| 货号：14493 | 规格：100 µg | 目录价：￥6216 |
产品详情
产品名称:
MIF (human, recombinant)
别名:
Macrophage Migration Inhibitory Factor
产品描述:
Macrophage Migration Inhibitory Factor (MIF) is a small, pro-inflammatory cytokine. MIF signaling is important in septic shock, arthritis, colitis, and cardiovascular diseases.{24687} MIF counteracts glucocorticoid signaling, which would otherwise inhibit inflammation. Secreted MIF binds to CD74 receptors, which then couple to CD44, during monocyte recruitment.{24685} In addition to CD44 binding, MIF is an enzymatically active keto-enol tautomerase that is inhibited by isothiocyanates such as sulforaphane.{24684} Overexpression of MIF has been seen in several cancers. MIF overexpression has been shown to promote hypoxia induced HIF-1α stabilization leading to changes in the tumor microenvironment, including stimulation of angiogenesis and neovascularization.{24686}
保存温度:
-80
运输温度:
-80
有效期:
180
纯度:
≥95% estimated by SDS-PAGE
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