Myeloperoxidase Monoclonal Antibody (Clone 2C8)-单抗-ELISA_抗体_蛋白_核苷酸

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Myeloperoxidase Monoclonal Antibody (Clone 2C8)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：15638

规格：1 ea (200 µg)

目录价：￥4410

产品详情

产品名称:

Myeloperoxidase Monoclonal Antibody (Clone 2C8)

别名:

MPO

产品描述:

Myeloperoxidase (MPO) is a heme-containing enzyme and the most abundant protein in polymorphonuclear leukocytes (PMNs).{57128} It is comprised of two subunits linked by a disulfide bridge with each subunit containing a light and a heavy polypeptide chain. It can oxidize a variety of substrates and catalyzes the formation of highly reactive (pseudo)hypohalous acids and radicals, including hypochlorous acid. MPO is stored in azurophilic granules of PMNs and is released from activated or necrotic PMNs, after which it can bind to and modify acidic serum proteins, as well as recruit additional PMNs. MPO also has roles in PMN apoptosis and antimicrobial defense systems, including neutrophil extracellular traps (NETs).{57128,23608,24590} MPO-deficient mice exhibit reduced survival in a polymicrobial sepsis model, increased susceptibility to experimental autoimmune encephalomyelitis (EAE), and increased atherosclerosis in mice also deficient in the LDL receptor and fed an atherogenic diet.{57128,57129,57127} Cayman's Myeloperoxidase Monoclonal Antibody (Clone 2C8) was developed by fusing the spleen of a non-immunized NZBWF1 mouse with a mouse myeloma cell line and can be used for immunofluorescence (IF) applications.

宿主来源:

Mouse

实验应用:

同种型:

IgG2b

克隆号:

2C8

保存温度:

-20

运输温度:

-20

产品形式: