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折扣/货期| 货号：15138 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
Nicotinamide N-Methyltransferase (human, recombinant)
别名:
NNMT
产品描述:
Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds.{24617} NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties.{24616,24618,24614} The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA.{24614,24772} Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.{24614}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 8.0, containing 500 mM sodium chloride, 5% glycerol, and 1 mM DTT
有效期:
180
纯度:
≥95% estimated by SDS-PAGE
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