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折扣/货期| 货号：90375-100 mg | 规格：100 mg | 目录价：￥1554 |
| 货号：90375-25 mg | 规格：25 mg | 目录价：￥448 |
| 货号：90375 | 规格：50 mg | 目录价：￥854 |
产品详情
产品名称:
Oleamide
别名:
cis-9-Octadecenamide
产品描述:
Oleamide is an amide of oleic acid (Item No. 90260) and an agonist of cannabinoid 1 (CB1) receptors (Ki = 8.13 µM in a radioligand binding assay).{11820} It is selective for CB1 over CB2 receptors, where it inhibits binding of the CB receptor full agonist CP 55,940 by only 42.5% in HEK-293T cells expressing human CB2 receptors when used at a concentration of 100 µM. Oleamide (10 µM) inhibits cAMP accumulation induced by forskolin (Item No. 11018) in N1E 115 mouse neuroblastoma cells, an effect that is reversed by the CB1 antagonist SR141716A. Oleamide was first identified in the cerebrospinal fluid of sleep-deprived cats, and it has also been detected in the cerebrospinal fluid of rats and humans.{1317} In rats, it induces physiological sleep when administered at doses ranging from 5 to 50 mg and increases food intake when administered into the nucleus accumbens shell, and in group-housed and socially isolated mice, it has anxiolytic-like effects.{1317,42212,42213} Oleamide also induces transactivation of PPARα, PPARβ, and PPARγ and inhibits activity of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) at concentrations in the low micromolar range.{32696}
保存温度:
-20
运输温度:
-20
预期分子量:
281.5
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
301-02-0
分子式:
C18H35NO
促销活动
