PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)-其他-ELISA_抗体_蛋白_核苷酸

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PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)

品牌：Cayman

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折扣/货期

货号：39108-1 g	规格：1 g	目录价：￥5726
货号：39108	规格：500 mg	目录价：￥3010

产品详情

产品名称:

PAMAM Dendrimer G3.5 Carboxylate (sodium salt) (water solution)

别名:

PAMAM G3.5 Carboxylate|Polyamidoamine Dendrimer G3.5 Carboxylate

产品描述:

PAMAM dendrimer G3.5 carboxylate (PAMAM G3.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro and in vivo.{67553,51539} It is approximately 66.1 Å in diameter in water and has 48 surface groups.{67554} PAMAM G3.5 is active against E. coli (IC50 = 22 mg/ml) and increases the mitochondrial membrane potential of isolated rat liver mitochondria when used at concentrations ranging from 10 to 50 µM.{51537,51538} Unlike amine-terminated PAMAM G4.0, PAMAM G3.5 (20 µM) is not toxic to zebrafish embryos.{51536} A fluorescently labeled form of PAMAM G3.5 enters Caco-2 cells via dynamin-, clathrin-, and caveolin-mediated endocytosis.{51535} Conjugates of PAMAM G3.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.08, 4.1, 0.39, and 3 µM, respectively).{67553} PAMAM G3.5 in complex with the topoisomerase I inhibitor camptothecin (Item No. 11694) increases the oral bioavailability of camptothecin in mice.{51539}

保存温度:

-20

运输温度:

-20

预期分子量:

12927.7

产品形式:

A solution in water

有效期:

730

CAS号:

192948-77-9