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折扣/货期| 货号：10007186 | 规格：1 ea | 目录价：￥1848 |
产品详情
产品名称:
PCSK9 (human) Blocking Peptide
别名:
NARC-1|Proprotein Convertase Subtilisin Kexin 9
产品描述:
To be used in conjunction with Cayman’s PCSK9 (human) polyclonal antibody (Catalog No. 10007185) to block protein-antibody complex formation during immunochemical analysis of PCSK9. · Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism.{13178} Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia which is characterized by an increase in low density lipoprotein (LDL) cholesterol levels.{13158} PCSK9 overexpression in wild-type mice doubles the plasma total cholesterol, possibly through acceleration of the degradation of the LDL receptor.{13176,13178} PCSK9 mRNA is detected in various tissues such as liver, kidney, lung, spleen, jejunum, ileum, colon, and muscle with the highest expression in the liver.{13136} Human PCSK9 precursor is 692 amino acid in length with an estimated molecular weight of 74 kDa. This proprotein is self-cleaved to form a mature protein at around 63 kDa in the golgi.{13177}
保存温度:
-20
运输温度:
-20
产品形式:
200 µg lyophilized peptide
有效期:
1095
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