货号:10218 | 规格:1 ea (500 µg) | 目录价:¥4410 |
产品详情
产品名称:
PCSK9 (human) Monoclonal Antibody (Clone 15A6)
别名:
NARC-1|Proprotein Convertase Subtilisin/Kexin Type 9
产品描述:
Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism.{13178} Gain-of-function mutations in the PCSK9 gene are associated with autosomal dominant hypercholesterolemia which is characterized by an increase in low-density lipoprotein (LDL) cholesterol levels.{13158} PCSK9 overexpression in wild-type mice doubles the plasma total cholesterol, possibly through accelerated LDL receptor degredation.{13178,13176} PCSK9 mRNA is detected in various tissues such as liver, kidney, lung, spleen, jejunum, ileum, colon, and muscle with the highest expression in the liver.{13136} Human PCSK9 precursor is 692 amino acids in length with an estimated molecular weight of 74 kDa. This proprotein is self-cleaved to form a mature protein at around 63 kDa in the Golgi body.{13177}
宿主来源:
Mouse
实验应用:
WB
同种型:
IgG1
免疫原:
Purified human recombinant PCSK9
克隆号:
15A6
保存温度:
-20
运输温度:
-20
产品形式:
500 µg of affinity-purified monoclonal antibody
有效期:
1095
来源:
Animal/Mouse
上一个:CD34 Monoclonal FITC Antibody (Clone ICO-115)
下一个:Phosphothreonine (Ascites) Monoclonal Antibody (Clone 18F6)
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