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折扣/货期| 货号：32564 | 规格：20 µg | 目录价：￥10008 |
产品详情
产品名称:
PKM2 (human, recombinant)
别名:
CTHBP|Cytosolic Thyroid Hormone-binding Protein|OIP3|Opa-interacting Protein 3|Pyruvate Kinase Muscle 2|THBP1|Thyroid Hormone-binding Protein 1
产品描述:
Pyruvate kinase (PK) is an enzyme that catalyzes the transfer of a phosphate group from phosphoenolpyruvate to ADP during aerobic glycolysis.{57358} PKM2 is an isoform of PK encoded by PKM in humans that is primarily expressed during embryonic development and localized to the cytosol. PKM2 expression is attenuated in adult tissues, however, it is reactivated in cancer cells during tumor development.{57358,57359,57361} It functions as a tetramer in the cytosol that is formed or dissociated in response to post-translational modifications and various allosteric regulators, such as fructose-1,6-bisphosphate, as well as the oxidation of its cysteine residues.{57360} It interacts with various tyrosine kinases, such as Bcr-Abl, A-RAF, and FGFR1, in a reciprocal interaction that regulates PKM2 enzyme kinetics and kinase signaling.{57359} PKM2 also functions as a dimer that can translocate to the nucleus and activate various transcription factors, including STAT3, NF-κB, and HIF-1α, to induce gene transcription.{57361,57359} Levels of PKM2 are increased in mesothelioma, osteosarcoma, and hepatomas, as well as ovarian, breast, gallbladder, and gastric cancers, and are associated with poor prognosis. Cayman’s PKM2 (human, recombinant) protein can be used for enzyme assay applications.
保存温度:
-80
运输温度:
-80
产品形式:
40 mM Tris-HCl, pH 8.0, with 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 20% glycerol, and 3 mM DTT
有效期:
180
纯度:
≥90% estimated by SDS-PAGE
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