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产品名称:
UBE3A antibody [HL1660]
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别名:
ubiquitin protein ligase E3A , ANCR , AS , E6-AP , EPVE6AP , HPVE6A
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产品描述:
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反应种属:
Human
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宿主来源:
Rabbit
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实验应用:
WB
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靶标/特异性:
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同种型:
IgG
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推荐稀释度:
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免疫原:
Recombinant protein encompassing a sequence within the center region of human UBE3A. The exact sequence is proprietary.
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免疫原种属:
Human
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克隆性:
Monoclonal
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克隆号:
HL1660
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纯化方式:
Affinity purified by Protein A.
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偶联:
Unconjugated
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产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
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表达系统:
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阳性对照:
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保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
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运输温度:
4°C
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细胞定位:
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预期分子量:
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产品形式:
Liquid
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存储溶液:
PBS, no preservative.
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有效期:
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产地:
美国
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外观:
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生产商:
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功能与背景:
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
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URL:
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检测方法:
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样本类型:
PBS, no preservative.
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生物活性:
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