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产品名称:
ATRX Antibody / RAD54
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别名:
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产品描述:
ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with thalassemia or ATRX syndrome .
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反应种属:
Human
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宿主来源:
Mouse
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实验应用:
IHC-P
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靶标/特异性:
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同种型:
Mouse IgG
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推荐稀释度:
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免疫原:
Recombinant full-length human ATRX protein was used as the immunogen for the ATRX antibody.
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免疫原种属:
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克隆性:
Monoclonal (mouse origin)
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克隆号:
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纯化方式:
Protein A/G affinity
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偶联:
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保存温度:
Aliquot the ATRX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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产品形式:
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存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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有效期:
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产地:
美国
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样本类型:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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