Glypican 3 Antibody / GPC3 - 深圳欣博盛生物科技有限公司

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Glypican 3 Antibody / GPC3

品牌： NSJ Bio

产品货号： V5365-20UG

规格： 20 ug

报价：

折后价：

数量： - +

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产品名称:

Glypican 3 Antibody / GPC3
别名:
产品描述:

Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
反应种属:

Human
宿主来源:

Rabbit
实验应用:

IHC-P
靶标/特异性:
同种型:

Rabbit IgG, kappa
推荐稀释度:
免疫原:

A recombinant partial protein sequence (within amino acids 400-550) from the human protein was used as the immunogen for the GPC3 antibody.
免疫原种属:
克隆性:

Recombinant Rabbit Monoclonal
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纯化方式:

Protein A affinity
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保存温度:

Aliquot the GPC3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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产地:

美国
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0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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