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Neurogenin 3 Antibody / NGN3
品牌： NSJ Bio
产品货号： V4091SAF-100UG
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    Neurogenin 3 Antibody / NGN3
  • 别名:
  • 产品描述:
    This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.
  • 反应种属:
    Human
  • 宿主来源:
    Mouse
  • 实验应用:
    IHC-P
  • 靶标/特异性:
  • 同种型:
    Mouse IgG2b, kappa
  • 推荐稀释度:
  • 免疫原:
    A recombinant partial protein (within amino acids 1-200) from the human protein was used as the immunogen for the Neurogenin 3 antibody.
  • 免疫原种属:
  • 克隆性:
    Monoclonal (mouse origin)
  • 克隆号:
  • 纯化方式:
    Protein A/G affinity
  • 偶联:
  • 产品浓度:
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  • 阳性对照:
  • 保存温度:
    Aliquot the Neurogenin 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 运输温度:
  • 细胞定位:
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  • 产品形式:
  • 存储溶液:
    1 mg/ml in 1X PBS; BSA free, sodium azide free
  • 有效期:
  • 产地:
    美国
  • 外观:
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  • 检测方法:
  • 样本类型:
    1 mg/ml in 1X PBS; BSA free, sodium azide free
  • 产品特点:
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  • 分子式:
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