-
产品名称:
Fas Antibody / CD95
-
别名:
-
产品描述:
mAb rB-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
-
反应种属:
Human
-
宿主来源:
Mouse
-
实验应用:
FACS, IF, IHC-F
-
靶标/特异性:
-
同种型:
Mouse IgG2a, kappa
-
推荐稀释度:
-
免疫原:
Recombinant human CD95 protein was used as the immunogen for the CD95 antibody.
-
免疫原种属:
-
克隆性:
Recombinant Mouse Monoclonal
-
克隆号:
-
纯化方式:
Protein A/G affinity
-
偶联:
-
产品浓度:
-
表达系统:
-
阳性对照:
-
保存温度:
Aliquot the CD95 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
运输温度:
-
细胞定位:
-
预期分子量:
-
产品形式:
-
存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
-
有效期:
-
产地:
美国
-
外观:
-
生产商:
-
功能与背景:
-
URL:
-
灵敏度:
-
检测范围:
-
检测方法:
-
样本类型:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
-
产品特点:
-
纯度:
-
生物活性:
-
内毒素水平:
-
来源:
-
表达方式:
-
Accession #:
-
CAS号:
-
分子式:
-
溶解度:
-
PubChem CID: