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产品名称:
MGMT Antibody
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别名:
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产品描述:
Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O6- alkylguanine position in DNA. MGMT transfers alkyl adducts from the O6- position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely to be drug resistant.
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反应种属:
Human
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宿主来源:
Rabbit
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实验应用:
IHC-P
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靶标/特异性:
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同种型:
Rabbit IgG, kappa
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推荐稀释度:
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免疫原:
A recombinant partial protein (within amino acids 1-100) from the human protein was used as the immunogen for the MGMT antibody.
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免疫原种属:
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克隆性:
Monoclonal (mouse origin)
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克隆号:
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纯化方式:
Protein A/G affinity
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保存温度:
Aliquot the MGMT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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产品形式:
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存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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有效期:
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产地:
美国
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样本类型:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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