WT1 Antibody / Wilms Tumor 1 - 深圳欣博盛生物科技有限公司

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WT1 Antibody / Wilms Tumor 1

品牌： NSJ Bio

产品货号： V4135-20UG

规格： 20 ug

报价：

折后价：

数量： - +

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产品名称:

WT1 Antibody / Wilms Tumor 1
别名:
产品描述:

The WT1 gene located at chromosome 11p13 codes for a transcription factor, a DNA-binding nucleoprotein, that plays a role primarily in the development of genitourinary organs. There are at least eight isoforms ranging between 52 and 62kDa produced by a combination of alternative splicing and RNA editing. WT1 is synthesized and reside in the cytoplasm in an inactive form. When activated through phosphorylation it is translocated to the nucleus. WT1 influences cell proliferation by suppressing bcl-2 and regulating cadherin and p53. In normal epithelia, nuclear WT1 expression is largely restricted to ovary (surface epithelium and inclusion cysts) and fallopian tube, while WT1 is not found in endometrial or cervical epithelium. As regards nonepithelial cells, nuclear WT1 is found in mesothelium and some sub mesothelial stromal cells, stromal cells of the female genital tract, testicular non-germinal cells, and kidney (podocytes). In tumor tissues, WT1 is detected in tumor cells of Wilms Tumor (also known as nephroblastoma) and mesothelioma. Additionally, WT1 expression has been found in ovarian serous carcinomas and some breast carcinomas.WT1 is particularly used for distinguishing malignant mesothelioma and ovarian serous carcinoma from nonserous carcinomas. As for malignant mesothelioma, calretinin and WT1 are superior to cytokeratin 5/6, N-cadherin and thrombomodulin. WT1 is also applicable for the differential diagnostic of small cell childhood tumors.
反应种属:

Human
宿主来源:

Mouse
实验应用:

IHC-P
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同种型:

Mouse IgG1, kappa
推荐稀释度:
免疫原:

A recombinant partial protein (within amino acids 150-350) from the human protein was used as the immunogen for the Wilms Tumor 1 antibody.
免疫原种属:
克隆性:

Monoclonal (mouse origin)
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Protein A/G affinity
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Aliquot the Wilms Tumor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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产地:

美国
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0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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