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产品名称:
CD3 gamma Antibody
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别名:
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产品描述:
The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge), a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g, e and d chains each contain a single copy of a conserved immunoreceptor tyrosinebased activation motif (ITAM). In contrast, the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.
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反应种属:
Human
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宿主来源:
Mouse
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实验应用:
IHC-P
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靶标/特异性:
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同种型:
Mouse IgG2c, kappa
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推荐稀释度:
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免疫原:
A recombinant partial protein sequence (within amino acids 1-182) from the human protein was used as the immunogen for the CD3 gamma antibody.
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免疫原种属:
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克隆性:
Monoclonal (mouse origin)
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纯化方式:
Protein A/G affinity
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保存温度:
Aliquot the CD3 gamma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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产品形式:
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存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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有效期:
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产地:
美国
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样本类型:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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