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产品名称:
HDAC7 Antibody
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别名:
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产品描述:
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC7 is a histone deacetylase that interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.
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反应种属:
Human
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宿主来源:
Mouse
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实验应用:
FACS
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靶标/特异性:
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同种型:
Mouse IgG
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推荐稀释度:
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免疫原:
Recombinant full-length human protein was used as the immunogen for the HDAC7 antibody.
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免疫原种属:
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克隆性:
Monoclonal (mouse origin)
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克隆号:
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纯化方式:
Protein A/G affinity
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偶联:
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表达系统:
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阳性对照:
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保存温度:
Aliquot the HDAC7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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运输温度:
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产品形式:
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存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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有效期:
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产地:
美国
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样本类型:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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