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产品名称:
BRCA2 Antibody
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别名:
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产品描述:
In 1990, a breast cancer susceptibility gene designated BRCA1 was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2 (breast cancer 2, early onset), located on chromosome 13q13.1, also confers a high incidence of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer. Both BRCA1 and BRCA2 play a role in the maintainance of genome stability, particularly in the homologous recombination pathway for double-strand DNA repair. BRCA2 is regarded as a tumor suppressor gene; tumors with BRCA2 mutations exhibit loss of heterozygosity (LOH) of the wildtype allele. The protein encoded by the BRCA2 gene contains multiple copies of a 70 amino acid motif called the BRC motif. These motifs effect binding to the Rad51 recombinase, which operates in DNA repair.
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反应种属:
Human
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宿主来源:
Mouse
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实验应用:
IHC-P
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靶标/特异性:
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同种型:
Mouse IgG1, kappa
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推荐稀释度:
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免疫原:
A recombinant partial protein sequence (within amino acids 200-500) from the human protein was used as the immunogen for the BRCA2 antibody.
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免疫原种属:
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克隆性:
Monoclonal (mouse origin)
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克隆号:
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纯化方式:
Protein A/G affinity
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阳性对照:
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保存温度:
Aliquot the BRCA2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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产品形式:
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存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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有效期:
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产地:
美国
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样本类型:
1 mg/ml in 1X PBS; BSA free, sodium azide free
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