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产品名称:
CCL23 Antibody / MPIF-1
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别名:
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产品描述:
Small inducible cytokine A23 precursor (CCL23), also called CK-b-8 and Myeloid Progenitor Inhibitory Factor 1 (MPIF-1), is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.
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反应种属:
Human
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宿主来源:
Mouse
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实验应用:
IHC-P
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靶标/特异性:
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同种型:
Mouse IgG2, kappa
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推荐稀释度:
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免疫原:
A recombinant partial protein sequence (within amino acids 1-120) from the human protein was used as the immunogen for the CCL23 antibody.
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免疫原种属:
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克隆性:
Monoclonal (mouse origin)
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克隆号:
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纯化方式:
Protein A/G affinity
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偶联:
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阳性对照:
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保存温度:
Aliquot the Myeloid Progenitor Inhibitory Factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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运输温度:
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产品形式:
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存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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有效期:
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产地:
美国
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样本类型:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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