Cytokeratin 14 Antibody / CK14 / KRT14 - 深圳欣博盛生物科技有限公司

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Cytokeratin 14 Antibody / CK14 / KRT14

品牌： NSJ Bio

产品货号： V4481-20UG

规格： 20 ug

报价：

折后价：

数量： - +

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产品名称:

Cytokeratin 14 Antibody / CK14 / KRT14
别名:
产品描述:

Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia.Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas.Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.
反应种属:

Human
宿主来源:

Mouse
实验应用:

IHC-P
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同种型:

Mouse IgG1, kappa
推荐稀释度:
免疫原:

A recombinant human KRT14 fragment (within amino acids 350-472) was used as the immunogen for the Cytokeratin 14 antibody.
免疫原种属:
克隆性:

Recombinant Mouse Monoclonal
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Protein A/G affinity
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Aliquot the Cytokeratin 14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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产地:

美国
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0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
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