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IFNAR1 Rabbit Monoclonal Antibody (Clone 110)
品牌： Cayman
产品货号： 38087-20 µL
规格： 20 µL

报价：
折后价：

数量： - +
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  • 产品名称:
    IFNAR1 Rabbit Monoclonal Antibody (Clone 110)
  • 别名:
    CRF2 member 1|CRF2-1|Cytokine Receptor Class-II Member 1|Cytokine Receptor Family 2 Member 1|Interferon Alpha/Beta Receptor 1|Interferon α/β Receptor 1|Type I IFN Receptor 1|Type I Interferon Receptor 1
  • 产品描述:
    α/β receptor 1 (IFNAR1), also known as type I IFN receptor 1, is a class II helical cytokine receptor involved in the antiviral response.{67238} It is composed of an extracellular domain, which contains four fibronectin type III subdomains, a transmembrane domain, and an intracellular domain, which contains a tyrosine kinase 2 (TYK2) phosphorylation site, and forms a heterodimer with IFNAR2.{67239} It is ubiquitously expressed and binds to type I IFNs, including IFN-α, IFN-β, and IFN-ω, which, upon binding, together with IFNAR2 signals through JAK1, TYK2, and various STATs.{67240} Knockout of Ifnar1 sensitizes fibroblasts to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vitro and has commonly been used as an immunosuppressive model to study viral infections in vivo.{67241,67242} SNPs in IFNAR1 are associated with increased risk of viral infections, lung cancer, multiple sclerosis, and cerebral malaria, as well as adverse reactions to vaccinations.{67238} Cayman’s IFNAR1 Rabbit Monoclonal Antibody (Clone 110) can be used for immunocytochemistry (ICC) and immunofluorescence (IF) applications.
  • 反应种属:
  • 宿主来源:
    Rabbit
  • 实验应用:
    ICC, IF
  • 靶标/特异性:
  • 同种型:
    IgG
  • 推荐稀释度:
  • 免疫原:
    Recombinant mouse IFNAR1
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    110
  • 纯化方式:
  • 偶联:
  • 产品浓度:
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  • 阳性对照:
  • 保存温度:
    -80
  • 运输温度:
    -80
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    50 or 100 µl of protein A-affinity purified monoclonal antibody
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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