anti-LRP5/6, mAb (rec.) (Heldy-1-4) - 深圳欣博盛生物科技有限公司

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anti-LRP5/6, mAb (rec.) (Heldy-1-4)

品牌： Adipogen

产品货号： AG-27B-0019-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-LRP5/6, mAb (rec.) (Heldy-1-4)
别名:

Low-density Lipoprotein Receptor-related Protein 5; LRP-5; Low-density Lipoprotein Receptor-related Protein 6; LRP-6
产品描述:

Wnt/beta-catenin signaling acts as a regulator of tissue development and homeostasis. Wnt ligands bind to a member of the Frizzled family of seven-transmembrane proteins and to either highly homologous low-density lipoprotein related receptors 5 (LRP5) or LRP6. Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-density lipoprotein receptor (LDLR) family. LRP5 and LRP6 are expressed in most human tissues and is composed of three distinctive cell-surface protein domains, including (1) LDL receptor (LDLR) type A repeats; (2) an epidermal growth factor (EGF)-like domain; and (3) a YWTD (Tyr-Trp-Thr-Asp)-type beta propeller domain. LRP6 is inhibited by the Dickkopf protein Dkk1 bound to their partners Kremen. Sclerotin also acts as an inhibitor of LRP5/6 through LRP4. LRP6 is involved in cell differentiation, proliferation and migration during embryonic development and in the pathogenesis of different cancer types. LRP6 plays a major role in metabolic regulation, specifically in the nutrient-sensing pathway. Patients carrying an LRP6 mutation exhibit high serum LDL cholesterol and triglycerides, hypertension, high fasting blood glucose levels, a prevalence of diabetes and low bone density. LRP6 mutations have also been associated with diseases such as Alzheimer's and degenerative joint diseases. LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density and plays a role in osteoporosis. LRP5 is aso involved in vitreoretinopathy.
反应种属:
宿主来源:

Produced without the use of animals. Purified from HEK 293 cell culture supernatant.
实验应用:

FACS
靶标/特异性:
同种型:

Human IgG2lambda.
推荐稀释度:
免疫原:

Recombinant mouse LRP6.
免疫原种属:
克隆性:
克隆号:

Heldy-1-4
纯化方式:
偶联:
产品浓度:

1mg/ml
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In PBS containing 10% glycerol.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. In PBS containing 10% glycerol.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: