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anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12)) (Fab Fragment) (His)
品牌： Adipogen
产品货号： AG-27B-6003PF-C100
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12)) (Fab Fragment) (His)
  • 别名:
    TNF-alpha-converting Enzyme; Disintegrin and Metalloproteinase Domain-containing Protein 17; CD156b
  • 产品描述:
    ADAM17 (Disintegrin and metalloproteinase domain-containing protein 17), also called TACE (Tumor necrosis factor-alpha-converting enzyme) is the prototype of the ADAM family of ectodomain shedding proteases (sheddase). ADAM17 is understood to be involved in the processing of TNF-alpha at the surface of the cell and from within the intracellular membranes of the trans-Golgi network. This process involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha) and is of known physiological importance. ADAM17 is responsible for the processing of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands and enzymes, including cleaving epidermal growth factor receptor (EGFR) ligands and extracellular Notch1. The proteolytic cleavage is an indispensable activation event for many of these substrates, ADAM17 has emerged as an attractive therapeutic target for the treatment of inflammatory diseases (e.g. rheumatoid arthritis) or inflammation associated cancer.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
    FUNC, FUNC (Blocking)
  • 靶标/特异性:
  • 同种型:
    Human Fab fragment, kappa, His-tagged
  • 推荐稀释度:
  • 免疫原:
    Recombinant human ADAM17 (TACE) ectodomain tagged to biotin.
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    D1(A12)
  • 纯化方式:
  • 偶联:
    Preservative Free
  • 产品浓度:
    1mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
  • 来源:
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  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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