anti-Phospho-Akt (Ser473) (human), Rabbit Monoclonal (RM251) - 深圳欣博盛生物科技有限公司

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anti-Phospho-Akt (Ser473) (human), Rabbit Monoclonal (RM251)

品牌： Adipogen

产品货号： REV-31-1131-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-Phospho-Akt (Ser473) (human), Rabbit Monoclonal (RM251)
别名:

PKB; AKT1; PKB alpha; EC=2.7.11.1; RAC-PK-alpha; Protein Kinase B; Proto-Oncogene c-Akt; Protein Kinase B alpha; PKBG; AKT3; STK-2; PKB gamma; RAC-PK-gamma; Protein Kinase Akt-3; Protein Kinase B gamma; AKT2; PKB beta; RAC-PK-beta; Protein
产品描述:

Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated at 2 phosphorylation sites Thr308 and Ser473. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad, forkhead transcription factors, c-Raf and caspase-9. In addition to its role in survival and glycogen synthesis, Akt is involved in cell cycle regulation. Akt also plays a critical role in cell growth by directly phosphorylating mTOR in a rapamycin-sensitive complex containing raptor. Mutation of the glutamic acid at residue 17 to lysine (E17K) of Akt was initially identified in human breast, colorectal and ovarian cancers. This conserved glutamic acid residue is located at the lipid-binding pocket of the Akt plextrin homology domain. The E17K mutation increases the affinity between Akt and phospholipids at the plasma membrane, leading to increased Akt recruitment, super-activation of the Akt pathway, cellular transformation and tumor formation. Additional studies detect the presence of the Akt (E17K) mutation in multiple cancers, including lung cancer, prostate cancer, endometrial carcinoma and several melanomas.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A phospho-peptide corresponding to human Phospho-Akt (Ser473).
免疫原种属:
克隆性:
克隆号:

RM251
纯化方式:
偶联:
产品浓度:
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阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
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URL:
灵敏度:
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检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
生物活性:
内毒素水平:
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PubChem CID: