anti-PTEN (human), Rabbit Monoclonal (RM265) - 深圳欣博盛生物科技有限公司

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anti-PTEN (human), Rabbit Monoclonal (RM265)

品牌： Adipogen

产品货号： REV-31-1147-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-PTEN (human), Rabbit Monoclonal (RM265)
别名:

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and Dual-specificity Protein Phosphatase; Mutated in Multiple Advanced Cancers 1; Phosphatase and Tensin Homolog
产品描述:

PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumor suppressor implicated in a wide variety of human cancers. PTEN encodes a 403 amino acid polypeptide and contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. PTEN preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating PI3K/Akt signaling pathway. PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites (Ser380, Thr382, and Thr383) that regulate PTEN stability and may affect its biological activity. PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis. PTEN plays a role as a key modulator in neurogenesis, including correct neuron positioning, dendritic development and synapse formation and it may be also a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A peptide corresponding to the C-terminus of human PTEN.
免疫原种属:
克隆性:
克隆号:

RM265
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
生物活性:
内毒素水平:
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PubChem CID: