anti-Cytokeratin-18 (human), Rabbit Monoclonal (RM279) - 深圳欣博盛生物科技有限公司

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anti-Cytokeratin-18 (human), Rabbit Monoclonal (RM279)

品牌： Adipogen

产品货号： REV-31-1162-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-Cytokeratin-18 (human), Rabbit Monoclonal (RM279)
别名:

CK18; CK-18; Cytokeratin 18
产品描述:

Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue (at least 20 different polypeptides). They are an important component of intermediate filaments, which help cells resist mechanical stress. Expression of these cytokeratins within epithelial cells is largely specific to particular organs or tissues. The subsets of cytokeratins which an epithelial cell expresses depends mainly on the type of epithelium, the moment in the course of terminal differentiation and the stage of development. Thus a specific cytokeratin expression profile allows the identification of epithelial cells. Furthermore, this applies also to the malignant counterparts of the epithelia, (carcinomas). Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. Cytokeratin-18 (Keratin 18; CK18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin-8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin-18. Further, cytokeratin-18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Mutations in the cytokeratin-18 gene have been linked to cryptogenic cirrhosis. During apoptosis, keratin filaments are altered and remarkably stable keratin fragments are generated. Activation of caspases leads to proteolysis of numerous cellular proteins, including structural components of epithelial cells. Cytokeratin-18 along with cytokeratin-8 are the major components of intermediate filaments in simple epithelial cells, and the only keratin pair in normal hepatocytes. Cytokeratin-18 is often used to identify differentiated isolated hepatocytes. During apoptosis, cytokeratin-8/cytokeratin-18 fragments are dramatically reorganized and cytokeratin-18 is cleaved by caspases at multiple sequence sites. Cleavage of cytokeratin-18 is an early event occurring during apoptosis.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A peptide corresponding to the N-terminus of human Cytokeratin-18.
免疫原种属:
克隆性:
克隆号:

RM279
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
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功能与背景:
URL:
灵敏度:
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检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
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