anti-CD45 (human), Rabbit Monoclonal (RM291) - 深圳欣博盛生物科技有限公司

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anti-CD45 (human), Rabbit Monoclonal (RM291)

品牌： Adipogen

产品货号： REV-31-1168-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-CD45 (human), Rabbit Monoclonal (RM291)
别名:

Receptor-type tyrosine-protein Phosphatase C; Leukocyte Common Antigen; L-CA; T200
产品描述:

CD45 (LCA; Leukocyte Common Antigen; Protein tyrosine phosphatase, receptor type, C; PTPRC) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, which differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions. Antibodies against the different isoforms of CD45 are used in routine immunohistochemistry to differentiate between immune cell types, as well as to differentiate between histological sections from lymphomas and carcinomas.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A peptide corresponding to the C-terminus of human CD45 (Receptor-type tyrosine-protein phosphatase C). .
免疫原种属:
克隆性:
克隆号:

RM291
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
生物活性:
内毒素水平:
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